Tissue Engineering Strategies for Improving Beta Cell Transplantation Outcome

Abstract Purpose of Review Beta cell replacement therapy as a form islet transplantation is promising alternative with the possibility to make selected patients type 1 diabetes (T1D) insulin independent. However, this technique faces challenges such extensive activation host immune system post-transplantation, lifelong need for immunosuppression, and scarcity donor pancreas. Advancement in tissue engineering strategies can improve these allow more widespread application therapy. This review will discuss recent development clinical translation beta Recent Findings Tissue offers innovative solutions producing unlimited glucose responsive cells fabrication appropriate devices/scaffolds applications. Generation pancreatic organoids supporting biocompatible biomaterials powerful function insulin-producing clusters. Fabrication physical barriers encapsulation protect from graft retrieval, although strategy still major fully restore physiological regulation. Summary The three main components including generation stem cell-derived possibilities therapeutic delivery cell-seeded devices extra-hepatic sites come together order provide safe functional